JD Wetherspoon will invest €15m in a new pub and 98-bedroom hotel on Dublin's Camden St.
It will begin working on the project in February 2018 and the development is set to open in early 2019.
The bar and hotel will employ 200 people.
"We are looking forward to developing the site into a fantastic pub and hotel ... It will be the biggest single investment undertaken by Wetherspoon and will result in our largest hotel alongside a superb pub," Tim Martin, Wetherspoon chairman commented.
"Our pubs in the Republic of Ireland are thriving and we are confident that the pub and hotel will be a great asset to Dublin and act as a catalyst for other businesses to invest in the city," he continued.
The pub area will be set over two floors and will include a beer garden.
The British chain currently has five pubs in the Republic of Ireland.