Officers from Revenue's Customs Service, assisted by Gardai, have seized cigarettes, spirits, beer, vehicles and cash - with a total value of almost 300,000 euro.
Revenue detection dogs Harvey, Frankie and Ben also assisted in the operation.
The operation involved a number of searches of both residential and commercial premises, under warrant, in Donegal, Mayo, Roscommon and Kildare.
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A number of people are being questioned and files are being prepared for prosecution.