Ahead of the vote, some have raised concerns about the exact wording of the proposed changes, including Ms Ryan.
She told Newstalk Breakfast she plans on voting no, but as a “protest vote”.
“It's about doing better, trying better, finding better words,” she said. “I just feel that the chosen amendment is a complete cop out.”
Ms Ryan said there are “tons and tons” of other relationships out there, and she has no issue with them being represented in the constitution.
“However, they are replacing it with ‘marriage or other durable relationships’, while also retaining the bit that says we will guard marriage with special care,” she said.
“There's no definition of what that means – what is a durable relationship? Who gets to decide that?
“This has serious implications, with my financial hat on, for pensions, for state pensions, welfare payments in the future.”
Referendum wording 'worse'
She noted that the current wording that the Government will “endeavour” to support women working in the home “doesn’t work”.
“Now, they’re replacing with 'endeavour to ensure’ to ‘strive to support’,” she said.
“Support is definitely a lesser word, to me, than ensure.
“It's becoming, ‘we're not even going to endeavour to ensure we're going to try our best.’
“They've never tried their best since the Constitution came into place.”
Ms Ryan said the provision about women in Búnreacht na hÉireann should “just should be taken out” rather than replaced.
People in favour of the referendum have argued the change is a "long-time coming". Others have pointed out the “gender neutral care provision” is more inclusive of all carers and is not an "attack" on women.