Pilots at Aer Lingus have begun an indefinite work-to-rule in a pay dispute with the airline.
It followed separate talks with the Labour Court which has told both parties it cannot intervene at this time.
The work-to-rule means pilots will not work overtime, not accept amendments to published rosters, not log into the Aer Lingus portal or answer phone calls outside of work hours.
Tens of thousands of passengers’ flights have been cancelled due to the indefinite work-to-rule.
Aer Lingus also announced the cancellation of a further 50 flights for July 1st and 2nd.
Pilots are also holding an eight-hour strike on Saturday from 5am to 1pm.
In a statement the airline said "implementing these cancellations is to enable us to protect as many services as possible for as many of our customers as possible".
"Customers whose flights are impacted will be communicated to directly via email/SMS, or through their travel agent, advising of their options," it said.
"While we will endeavour to re-accommodate customers where possible the levels of disruption may not make this possible."
The announcement comes as Taoiseach Simon Harris called on Aer Lingus and the Irish Air Line Pilots' Association (IALPA) to “dig deep” in attempting to come to a resolution in their heated industrial dispute.
The industrial action is being taken by members of IALPA which is seeking a pay increase of 24% for Aer Lingus pilots.