Hundreds more foreign nationals are expected to leave Gaza later today.
It comes after yesterday saw the first evacuations from the territory since the start of the conflict between Israel and Hamas nearly a month ago.
A total of 76 wounded people and their companions left Gaza in ambulances yesterday through the Rafah border, according to a spokesman for the Palestinian Crossings Authority.
Around six buses carrying 335 foreign nationals also departed into Egypt, the spokesman added.
The Rafah border will be open again on Thursday to allow foreign passport holders out of Gaza, the authority confirmed.
A deal, mediated by Qatar, was struck between Egypt, Israel and Hamas to open the crossing to foreign and dual nationals currently trapped in Gaza.
Footage broadcast on Egyptian state TV showed injured people being transported in ambulances across the border from the Gaza Strip.
Egypt's health ministry said a field hospital has been set up in an Egyptian town near the crossing.
It is believed no Irish citizens were included in the first group crossing the border.
The Italian foreign minister confirmed four Italian citizens, one of whom was accompanied by his Palestinian wife, were among those who have already left Gaza.
Rafah is Gaza's only gateway to the rest of the world not directly controlled by Israel.
It is under the control of Egypt as part of an agreement with Israel and the European Union.
However, it has never been a normal, fully open border crossing and is tightly controlled by authorities in Cairo.
US President Joe Biden has said he thinks there should be a humanitarian 'pause' in the fighting between Israel and Hamas in Gaza, to 'get prisoners out.'
He was interrupted during a speech in the US state of Minnesota on Wednesday.
Breaking: Rabbi Jessica Rosenberg is interrupting President Biden demanding a CEASEFIRE NOW. She is speaking on behalf of thousands of American Jews who say Not In Our Name! We refuse to allow a genocide be carried out in our names.
Ceasefire Now to save lives! pic.twitter.com/m5fR8OdoOk— Jewish Voice for Peace (@jvplive) November 1, 2023
Rabbi Jessica Rosenberg stood up in the crowd and told him: "Mr President, if you care about Jewish people - as a Rabbi - I need you to call for a ceasefire right now."
The group Jewish Voice for Peace, which describes itself as "Jews organizing toward Palestinian liberation and Judaism beyond Zionism", said Rabbi Rosenberg was "speaking on behalf of thousands of American Jews who say Not In Our Name."
"We refuse to allow a genocide be carried out in our names," it added.
Pressure for humanitarian pause
Tánaiste Micheál Martin told The Pat Kenny Show on Wednesday there needs to be a humanitarian ceasefire now.
On a missile strike on the Jabalia refugee camp in northern Gaza, he said: "Whole families destroyed, killed, fathers talking about losing their children; it's horrific and it's not justifiable and in our view, it adds pressure to the need to have a humanitarian pause here, a humanitarian ceasefire to enable aid to get in."
Minister Martin said Israel has a right to go after Hamas but the missile strike was not a proportionate response.
"When you bomb a refugee camp which is a town in itself of long duration - it's there for many, many decades - there is no doubt, many, many civilians will be killed," he said.
"Children will be killed and I do not believe it was a proportionate attack last evening in any shape or form," he added.
Additional reporting: IRN