The head of the HSE says his organisation remains "highly committed" to the proposed Sláintecare reforms.
It comes after two senior officials involved in the plan resigned from their roles.
The sweeping reform programme is aimed at ending the current two-tiered health system in Ireland.
It would see HSE powers devolved into regions, and commits to changes including universal healthcare and free GP care.
Last week two senior members involved in the programme - Executive Director Laura Magahy and the Chair of the Sláintecare Implementation Advisory Council Professor Tom Keane - resigned from their positions.
In his resignation letter, Professor Kean said he'd come to the conclusion that "requirements for implementing this unprecedented programme for change are seriously lacking".
Róisín Shortall, the chair of the Oireachtas committee that launched the plan, says it's clear the two officials were "very frustrated" and the Health Minister should now set out exactly what the concerns were.
Some health experts, including DCU Professor Anthony Staines, have claimed the Department of Health is not capable of delivering the reform programme.
HSE CEO Paul Reid, however, says he still fully backs the reform plans.
Speaking to On The Record, he dismissed any suggestion that the healthcare system here is resistant to change - pointing to the rapid changes brought in during the pandemic.
He said major reform is needed, and the structures in place do need to be simplified.
He said: “We have to pick it up and keep moving on - and we will move on.
"We need to commit to it... [in the HSE] we're highly committed to all aspects of it.
"The public deserves it... to address issues like the waiting list, regionalisation and integration."
He said he can't comment on the officials' reasons for resigning, but he does know there is a commitment to reform and challenges that must be addressed.
He added: "When I took up the role of CEO of the HSE, I was particularly quite enthused and excited by the reform agenda.
"I'm still highly committed to it... the board of the HSE is highly committed to all aspects of it."
