Nurses and midwives with the INMO have voted to accept proposals to end their industrial dispute.
62% of INMO members voted in favour of the proposals.
It follows three days of strike action in January and February as a result of a dispute over staff shortages and pay.
Measures put forward to resolve the dispute include a commitment to safe staffing levels, and a higher salary scale for staff nurses and midwives.
An independent expert group will also look at pay for those in managerial grades, while extra promotional opportunities are also being pledged.
INMO General Secretary, Phil Ní Sheaghdha, said: "INMO nurses and midwives fought hard for patient safety and staffing in a determined, controlled and collective manner. We are extremely proud of the safe, patient-focused strike organised by our strike committees.
"The government have committed to full implementation of these proposals. We now seek an immediate meeting with them to ensure this happens without delay."
She added: "I would like to thank the public who showed Ireland's nurses and midwives such support during our strike days."
Health Minister Simon Harris welcomed the result of the ballot:
Welcome news that nurses and midwives have voted to accept the agreement with the Government. Good for nurses. Good for patients. Good for our health service
— Simon Harris TD (@SimonHarrisTD) May 2, 2019
The strikes earlier this year saw major disruption in hospitals across the country, with tens of thousands of procedures cancelled.
Labour Court proposals to end the strike included €5 million in funding for safe staffing levels in 2019, with extra funding in 2020 and 2021.