NPHET will meet this morning to discuss the recent rise in COVID-19 cases.
Chief Medical Officer Dr Tony Holohan says the country is in a "precarious situation" as the virus is going in the "wrong direction".
Six further deaths and 431 new cases were confirmed last night, with Dr Holohan describing the upward trend as "troubling".
More restrictions are due to be lifted tomorrow allowing people to travel anywhere in Ireland.
Households will also be allowed to mix with up to two other households - meaning a total of three households will be able to meet together.
The former HSE Director General Tony O'Brien believes it should now be reviewed.
He said that Dr Holohan was "quite right" to express his worry over the increase in coronavirus cases yesterday as the figures were "concerning".
Mr O'Brien added: "I think it is therefore necessary for the Government to consider whether the proposed opening up over the Christmas period and for the length of time over the Christmas period is still a safe and reasonable thing to do."
Meanwhile, 386 pupils and more than 20 staff at a primary school in Co Kerry have been asked to restrict their movements until December 30th following a large outbreak of COVID-19.
The HSE has informed parents of students at Scoil Mhuire in Killorglin that 17 cases of the virus have been identified at the mixed school.
It says all staff and students will now be tested following one of the largest outbreaks in a school to date.
The Stormont Parliament Buildings in east Belfast. Photo: Paul McErlane/XinhuaNorthern Ireland
In Northern Ireland, Health Minister Robin Swann will bring a number of new proposals to the Stormont Executive today on limiting the spread of COVID-19.
Deputy first minister Michelle O'Neill believes there is '"no doubt" that intervention is needed.
Hospitals are operating at 105% capacity, with doctors forced to treat patients in ambulances at Antrim Area Hospital yesterday.
510 new cases of the virus were confirmed there yesterday in addition to eight further deaths.
The British Medical Association is now calling for intensive care staff from the Republic to be sent to the North to cope with its crisis.
The North's strict restrictions were lifted last Friday, but Professor Gabriel Scally is calling for the region to go back into lockdown.
He said "urgent measures" such as going back to "a great deal of social restrictions" are needed until the numbers come down.
Dr Scally added: "It will have to be a solitary Christmas and we'll have to rely on electronic communication with people.
"All of that restriction should go on for some time until the cases come down and the health service can cope in the North."
