More than 2,000 people aged under 30 resigned from the Health Service Executive (HSE) last year.
According to Freedom of Information figures obtained by Newstalk, it is an increase of 15% on the previous year.
Some 7,257 HSE staff aged under 65 resigned from the HSE in 2021 - almost 1,000 more than the previous year.
In 2019, 1,159 people under 30 quit, rising to 1,756 in 2020 and increasing again to 2,026 last year.
Beaumont Hospital consultant Bill Tormey says there are several factors.
"In the last two years, there's been a massive increase in stress on the job because of the effects of the COVID-19 crisis: burnout, over-work".
Galway GP Martin Daly says many people leave the HSE to work abroad in places like New Zealand, Australia, the UK and Canada.
"Many of the reasons for which they go would appear to be a culture within the organisation of the HSE.
"A lack of career pathways in which they can advance professionally.
"And many of them will express the view that they are not valued in our own system, whereas they feel valued where they work abroad".
The HSE says there are several reasons people choose to leave the organisation; including family or personal reasons, end of contract or training or retirement.
