Primark has suspended placing new orders in Myanmar following last month's military coup.
The company - which trades as Penney's in Ireland - uses 21 factories in Myanmar.
Clothing chains H&M and Benetton have also paused business there.
Troops seized power in Myanmar - also known as Burma - after claiming November's election was fraudulent.
Last week, over 100 protesters were reportedly killed by security forces in the deadliest day since February's coup.
The Department of Foreign Affairs has advised Irish citizens in the country to leave due to the ongoing violence.
Foreign Affairs Minister Simon Coveney said he was "deeply shocked and saddened by the abhorrent and indefensible killing of unarmed civilians, including children".
The military's actions in Myanmar have drawn widespread condemnation - with two top UN officials saying the attacks on peaceful protesters were "shameful, cowardly and brutal".
They say the country's military must now be fundamentally reformed, as past atrocities - such as violence against Rohingya and other minorities - have also not been addressed.
