Up to 40,000 passengers will be impacted by the latest cancellations.
Ryanair has cancelled 220 flights scheduled on the bank holiday due to to air traffic controller strikes in France.
Up to 35 flights that are scheduled to leave or arrive in Dublin tomorrow will reportedly be cancelled.
Speaking from Ryanair's Dublin Operations Centre, CEO Michael O'Leary says it's unacceptable that local French flights are protected - while 'overflights' from other countries are left to bear the burden of continued strikes.
"France is using minimum service legislation to protect its local French flights," he said. "But all the cancellations are then being disproportionately passed on to English flights, Irish flights, Italian flights, Spanish flights, German flights."
Mr O'Leary called on European Commission President Ursula von der Leyen to "take action to protect overflights".
"Protect Europe's single market for flying," he urged.
The French Aviation Authorities previously gave notification of strike action, and French airports were asked to cancel flights over the weekend.
Michael O'Leary: ''We've been notified by the French Aviation Authorities of the 51st day of striking, on Monday May 1st, and that we must cancel another 220 flights, impacting 40,000 passengers..this is unacceptable'' pic.twitter.com/KmAiY9wCrn
— Ryanair (@Ryanair) April 29, 2023
He also called on customers to sign a petition on the Ryanair website urging the European Commission to take action. It has reached 630,000 signatures so far.
On Friday, several French airports were asked to cancel their flights due to industrial action.
The French air traffic control strike action on Bank Holiday Monday will be the 51st day of strike action in recent months.
Air traffic controllers are protesting President Macron's proposed pension reforms, under which France's legal retirement age will gradually increase from 62 to 64.
Ryanair has already attributed more than 3,700 flight cancellation this year to strike action.