The Taoiseach is meeting with the Palestinian Authority President in New York.
It will be the first bilateral meeting between Simon Harris and President Mahmoud Abbas since Ireland recognised the State of Palestine in May.
The meeting on Tuesday comes against the backdrop of an ongoing human catastrophe in Gaza and growing attacks in the West Bank.
The Taoiseach will meet with President Abbas on the efforts for a ceasefire, efforts to release Israeli hostages and the urgent need for aid to flow into Gaza.
Speaking ahead of the meeting, Mr Harris said he will be offering support to Palestine.
"Ireland recognised the State of Palestine to help keep alive the hope of a two-state solution with Palestine and Israel living peacefully side-by-side," he said.
"Today I will be asking President Abbas how we can support him and the Palestinian Authority in making that hope a reality. Ireland knows how important it is for a country to take its place on the global stage."
Tensions continue to ratchet up in the Middle East with reports of hundreds of retaliatory Israeli strikes on Hezbollah targets in southern Lebanon on Monday which have reportedly left nearly 300 dead.
There were also strikes in Gaza including on a refugee camp, according to UN humanitarians.
The UN mission patrolling the Blue Line separating Lebanon and Israel UNIFIL, which includes Irish troops, has expressed "grave concern for the safety of civilians", amid what has been the deadliest day of violence and bombing by Israel since the October terror attacks sparked the regional crisis.
UN Secretary-General António Guterres said he was "gravely alarmed by the escalating situation along the Blue Line and the large number of civilian casualties, including children and women, being reported by the Lebanese authorities".
The Taoiseach will also hold bilateral meetings with King Abdullah of Jordan and Mr Guterres.
Both the Taoiseach and President Michael D Higgins are in New York for the official opening of the United Nations General Assembly.
