Ulster Bank has confirmed it will cut 266 jobs as part of plans to reduce costs.
213 of those roles will be cut in the Republic, with the remaining 53 going in Northern Ireland.
The bank says it is hoping to reduce its workforce through voluntary redundancies where possible.
Additionally, some fixed-term positions will not be renewed and operational changes will be implemented.
The bank has assured that no branches will be closed as part of its cost-cutting measures.
As part of the plans, 57 new roles will be created, with 29 of those in the Republic and 28 in the North.
An Ulster Bank spokesperson said: “We have announced the next phase of our programme to reduce our costs which includes operational changes and a reduction of 266 roles, which we aim to achieve on a voluntary redundancy basis, where possible.
"A small number of roles have also been created.
"We know this is difficult news for our colleagues and we are doing everything we can to support those affected by the changes.”