The Department of Foreign Affairs says it is tracking the cases of some 150 Irish citizens who were believed to have been in Nepal at the time of the earthquake.
The vast majority of these citizens have now been accounted for and are safe and well.
However there are currently 10 citizens on the Department's list with whom contact has yet to be made.
"Some of these people may be in remote areas where communications would be sporadic at the best of times, which means it is taking time to formally account for all Irish citizens. There are no suggestions at this stage of any Irish fatalities," Foreign Affairs Minister Charlie Flanagan said.
One Irish citizen has been injured but is stable, and is due to be medevac'd when flight clearance allows - Mr Flanagan added.
Meanwhile the death toll from Nepal's devastating earthquake could reach 10,000, the country's prime minister has said. It has so far risen to 5,057 - with another 61 known to have died in India and 25 in Tibet.
It comes as aid workers plead for food and medicine for dozens of villages cut off by landslides and people frustrated by the government's slow response use their bare hands to dig for survivors.
"The government is doing all it can for rescue and relief on a war footing," Prime Minister Sushil Koirala said. "It is a challenge and a very difficult hour for Nepal.
"The death toll could go up to 10,000 because information from remote villages hit by the earthquake is yet to come in."
Landslides have blocked roads to many of the communities in rugged terrain normally only reachable by four-wheel drive vehicles.
More than 4,350 people are now known to have died since Saturday's 7.8-magnitude quake, but authorities say eight million are affected.
While some 250 people are missing after an avalanche in Rasuwa, a trekking area north of Kathmundu.
All of the climbers who had been stranded at camps high up Mount Everest have been helicoptered to safety, but planes have been struggling to land at Kathmandu Airport where the runway does not have enough parking space for all the aircraft.
Thousands are fleeing the fear of aftershocks in the capital, causing long tailbacks on the narrow mountain roads which are hampering the relief effort.
Rescue workers say it could be weeks before they are able to reach many of the victims.
In some villages and towns, including Gorkha where 223 have died, up to 75% of buildings are reportedly destroyed.
Hundreds of funerals have been taking place, with mass cremations creating palls of smoke above the city.
Rescuers from Russia, Japan, France, Switzerland, Taiwan and Singapore are expected in Kathmandu over the coming days.
Lila Mani Poudyal, Nepal's chief secretary and rescue coordinator, said: "We are appealing for tents, dry goods, blankets, mattresses, and 80 different medicines. We don't have the helicopters that we need or the expertise to rescue the people trapped."
Darren Hanniffy, senior manager with GOAL, arrived in Kathmandu last night.
He told Newstalk Breakfast earlier that people there are still in shock.
John Roche of the Irish Red Cross says poor infrastructure is making the situation more difficult.
