Leaders Manchester United kick off 2013 with a 7-point lead over the chasing pack.
They go to local rivals Wigan.
Champions, and second placed, Manchester City host Stoke.
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Tottenham take on Reading knowing a win at White Hart Lane would send them third.
Theo Walcott returns to Southampton as Arsenal take on the Saints in the tea time game.
Norwich are at West Ham and Swansea welcome an Aston Villa team who've conceded 15 goals in their last 3 matches.