Arsenal host West Brom in the pick of the games.
The Gunners have been in poor form in recent weeks and fell to 10th after defeat at home to Swansea last week.
But West Brom have also suffered a loss of form with two successive defeats.
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Chelsea go in search of their first league win under Rafa Benitez - they are away to struggling Sunderland.
There is a relegation battle at St Mary's where Southampton will host Reading while bottom-of-the-table QPR are away Wigan.
Elsewhere, Aston Villa play host to Stoke, while Swansea are at home to Norwich.