Arsenal are aiming to move up to third place in the Premier League.
The Gunners kick off away to Wigan at 12.45pm.
Manager Arsene Wenger made several changes in their win over Reading, including starting Theo Walcott as a striker.
Wenger will give the England International another chance up front:
At 3pm, Manchester City can move back to within three points of Manchester United - they are at home to Reading.
Tottenham will also be looking to move above Chelsea with a win at home to Stoke.
Elsewhere, Everton visit West Ham and West Brom clash with Norwich at the Hawthorns.
At the bottom, QPR visit Newcastle and Southampton can keep themselves out of the drop zone with a win over a Sunderland side that are just above them in the table.
The late game is at Anfield, where Liverpool will entertain Fulham from 5.30pm.