Connacht winger Niyi Adeolokun will miss the next three weeks after damaging his knee during Sunday's Pro 12 win over Treviso.
The 24-year-old suffered a ligament spain in what has been an injury hit season for him so far.
Tighthead prop Nathan White will also miss Friday's trip to the Cardiff Blues with a calf injury.
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But there is better news in relation to Mils Muliana and Darragh Leader, who are both available for the visit to the Arms Park.