Bundee Aki, Tadhg Furlong, Ronan Kelleher and Jack Conan will see game time this weekend in the United Rugby Championship.
Connacht travel to Thomond Park to play Munster on Saturday and coach Andy Friend has made five changes from the side which lost to the Dragons last weekend.
Aki makes his first start since the tour of South Africa, with Sammy Arnold, John Porch, Niall Murray, and Conor Oliver also coming into the side.
The Connacht Rugby team reads:
15. Tiernan O’Halloran
14. John Porch
13. Sammy Arnold
12. Bundee Aki
11. Mack Hansen
10. Jack Carty (C)
9. Caolin Blade
1. Matthew Burke
2. Dave Heffernan
3. Finlay Bealham
4. Niall Murray
5. Ultan Dillane
6. Cian Prendergast
7. Conor Oliver
8. Paul Boyle
Munster coach Johann van Graan has made 14 changes to the side which won away to the Scarlets.
Second row Chris Cloete is the only player returned as Munster field the big-guns, with Peter O'Mahony skippering the side.
The Munster Rugby team reads:
15. Mike Haley
14. Andrew Conway
13. Keith Earls
12. Rory Scannell
11. Simon Zebo
10. Joey Carbery
9. Craig Casey
1. Dave Kilcoyne
2. Niall Scannell
3. John Ryan
4. Jean Kleyn
5. Tadhg Beirne
6. Peter O’Mahony (C)
7. Chris Cloete
8. Gavin Coombes
Munster v Connacht in the United Rugby Championship kicks off at 7.35 pm at Thomond Park on Saturday.
For Leinster Rugby, Lions Tadhg Furlong, Rónan Kelleher and Jack Conan are back in their starting 15 for their encounter against the Scarlets at the RDS on Saturday.
Johnny Sexton captains the team from out-half, which lines out as follows:
15. Hugo Keenan
14. Jordan Larmour
13. Garry Ringrose
12. Ciarán Frawley
11. James Lowe
10. Johnny Sexton (C)
9. Jamison Gibson-Park
1. Andrew Porter
2. Rónan Kelleher
3. Tadhg Furlong
4. Ross Molony
5. James Ryan
6. Caelan Doris
7. Josh van der Flier
8. Jack Conan
Leinster v Scarlets in the United Rugby Championship kicks off at 5.15 pm at the RDS on Saturday.