James Lowe will make his debut for Ireland against Wales in Friday's Autumn Nations Cup game at the Aviva Stadium.
The 28-year-old Leinster winger has been named on the wing by Andy Farrell and is part of a back three that also includes Jacob Stockdale and Hugo Keenan..
Lowe's Leinster team-mate Jamison Gibson-Park will make his first start at scrum-half and links up with captain Johnny Sexton in the half-backs.
The other change in the backline from the loss to France sees Chris Farrell start in the centre.
Robbie Henshaw switches to inside centre with Chris Farrell coming in at 13.
In the pack, Leinster hooker Ronan Kelleher gets the nod over Rob Herring, while Iain Henderson returns to the second row alongisde James Ryan.
Peter O'Mahony and Josh van der Flier come into the back row alongside Caelan Doris, who moves to number 8.
Ulster's Billy Burns is in line to make his debut after being named among the replacements.
#TeamOfUs
Andy Farrell has named 2⃣ uncapped players in his Match Day 23 for Friday's #GuinnessSeries clash against Wales ☘️ ⤵️#ShoulderToShoulder #AutumnNationsCup #IrishRugby #IREvWAL https://t.co/eLijDYHuFo— Irish Rugby (@IrishRugby) November 10, 2020
Conor Murray and Keith Earls are named among the replacements with Dave Heffernan, Ed Byrne, Finlay Bealham, Quinn Roux and Will Connors.
Ireland team:
15. Jacob Stockdale
14. Hugo Keenan
13. Chris Farrell
12. Robbie Henshaw
11. James Lowe
10. Jonathan Sexton
9. Jamison Gibson Park
1. Cian Healy
2. Ronan Kelleher
3. Andrew Porter
4. Iain Henderson
5. James Ryan
6. Peter O’Mahony
7. Josh van der Flier
8. Caelan Doris
Replacements
16. Dave Heffernan
17. Ed Byrne
18. Finlay Bealham
19. Quinn Roux
20. Will Connors
21. Conor Murray
22. Billy Burns
23. Keith Earls
