Tottenham will be hoping to take their early season form into their clash with Aston Villa at Villa Park. Spurs are joint top along with Arsenal but Villa also returned to winning ways away to Norwich on Saturday. However Christian Benteke is unlikely to feature after his injury against the Canaries.
West Ham and Cardiff meet for the second time this season at Upton Park. On the opening day, the Hammers beat the Welsh side 2 - 0. But Joe Cole and Stewart Downing are out for West Ham.
Darron Gibson may return to action as Fulham host Everton at Craven Cottage at 8pm. The Ireland midfielder has been out of action at the start of the season with a knee injury.
Elsewhere Hull entertain Championship side Huddersfield Town at the KC Stadium, while Man City and Wigan meet at the Ethiad in a repeat of last season's FA Cup Final.
The other ties involving Premier League sides see Southampton host Bristol City, Norwich visit Championship promotion-chasers Watford and the clash of League One outfit Swindon and Chelsea.
Jose Mourinho is likely to give a rare start to Juan Mata and David Luiz who have been marginalized at times this season.
