Ulster, currently at the top of the league tables, can guarantee a home semi with a win over Cardiff at Ravenhill. Second-placed Leinster, meanwhile, will get a home semi if they match or better Glasgow’s result against Connacht at the Sportsgrounds.
Newly-appointed Ireland manager Joe Schmidt’s Leinster squad are at home to Ospreys. The Welsh team need a victory to leapfrog fourth-placed Scarletts (who play Treviso tonight).
Sixth-placed Munster are away to Zebre in Italy.
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All of tonight's six games kick off at 7.45pm.