Arsenal will play host to arch-rivals Tottenham, with Gunners fans hoping that the game will not mark a shift in power between the two clubs.
Arsenal go into today"s 12.45 kick-off in eighth place in the table and 11 points behind leaders Manchester United.
But Arsene Wenger still believes his side are title contenders...
Man United will be involved in the evening game as they visit Chris Hughton"s Norwich side from 5.30pm.
Last season the Reds needed a 90th minute winner from Ryan Giggs to claim all three points and with United having fallen behind in eight of their ten wins so far, Norwich will know any lead they take will be under threat.
If United drop points, Manchester City and Chelsea will be in with a chance of taking over the top of the Premier League - at least for a few hours - as they both feature in the 3pm kick-offs.
City host Aston Villa while the Blues will travel to face West Brom, where they will come up against former first-team coach Steve Clarke.
Liverpool will be looking to break back into the top half of the table as they host Wigan at Anfield.
But the Latics shocked the Reds at Anfield last season which will make Brendan Rodgers very wary indeed.
In the other afternoon kick-offs, Swansea travel to Newcastle, while Reading host Everton and the bottom-two in the table, QPR and Southampton, go head-to-head at Loftus Road.
