Today’s action is at Anfield and Loftus Road.
QPR v Reading 1.30pm
QPR are still bottom of the league after nine games, but Reading are not faring much better in 18th place.
Rangers’ boss Mark Hughes has targeted this fixture as a must win game and his opposite number Brian McDermott will feel the same.
But QPR are without Stephane Mbia through suspension and captain Park Ji Sung, Bobby Zamora and Armand Traore are all major doubts to start.
Reading were involved in the exciting 7 – 5 League Cup extra-time defeat in midweek and McDermott could be tempted into some changes, although he has no major injury worries to contend with.
Prediction: 3 – 2
Liverpool v Newcastle 4pm
Steven Gerrard is set for his 600th appearance for the club as the Reds aim for a top half place.
Brendan Rodgers rested a number of players for the midweek league cup defeat to Swansea but goalkeeper Pepe Reina and Glen Johnson are out with hamstring injuries.
The Magpies will be hoping to enter the top six today if they can pull off a win at Anfield.
But Newcastle have not won at the famous stadium since 1994.
Alan Pardew is missing tenacious midfielder Cheick Tiote as he continues to serve a three match ban for his sending off in the Tyne-Wear derby.