West Ham humbled Man United at the London Stadium in the early kick-off on Saturday, piling even more pressure on manager José Mourinho.
Goals from Felipé Anderson, an own-goal from Victor Lindelof and an Marko Arnautovic strike gave the Hammers a comfortable win despite a tidy finish from Marcus Rashford to give the visitors a lifeline at 2-1.
The loss leaves United five points off the top four and they host Newcastle next weekend before they head to Stamford Bridge to face Mourinho's old side, Chelsea, after the international break.
Dan McDonnell and Johnny Ward joined Will O'Callaghan on Saturday's Off the Ball with McDonnell believing the time might be coming for a change of leadership at Old Trafford, saying: "I think we were speaking about this a couple of weeks back and I felt the next crises, the next really major defeat - he'd be in bother.
"I think today probably ticks the box. I don't know - there's an international break coming up so if there's a time, there comes this 'stick or twist' point to a degree where the season has run away from you and did he leave Chelsea in December the season that he went?
"But, there are these windows where you can make a change and once you go beyond a certain one - there's a possibility they get a bit of form there and a deceiving run but you're always one strike from being out at that point.
"Pogba isn't going anywhere until January so he's there so I think it could be pretty soon!"